https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48703 Wed 29 Mar 2023 14:08:59 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45081 −/−) have increased baseline anxiety behaviors, SERT^+/− rats with low SERT expression (and more relevant to the clinical condition with low SERT expression) do not. Yet, no systematic studies of fear acquisition/extinction or their underlying neural mechanisms have been conducted in this preclinical genetic SERT^+/− model. Here we sought to determine if SERT^+/− or SERT^−/−, compared to wildtype, rats would show exacerbated panic responses and/or persistent conditioned fear responses that may be associated with PTSD or phobia vulnerability. Results: Only SERT^−/− rats showed increased baseline anxiety-like behaviors with heightened panic respiratory responses. However SERT^+/− (also SERT^-/-) rats showed enhanced acquisition of fear and delayed extinction of fear that was associated with changes in serotonergic-related genes (e.g., reduced 5-HT1A receptor) and disrupted inhibition within the basolateral amygdala (BLA). Furthermore, the disrupted fear responses in SERT^+/− rats were normalized with 5HT1A antagonist infusions into the BLA. Enhanced acquisition and failure to extinguish fear memories displayed by both SERT^−/− and SERT^+/− rats are cardinal symptoms of disabling anxiety disorders such as phobias and PTSD. The data here support the hypothesis that reduced SERT function is a genetic risk that disrupts select gene expression and network properties in the amygdala that could result in vulnerability to these syndromes.]]> Wed 26 Oct 2022 12:02:46 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17162 Wed 11 Apr 2018 15:12:13 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13436 Wed 11 Apr 2018 14:11:32 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29433 n = 282, age M = 60.79, SD = 5.05), (b) a sub-sample of partners of Australian combat veterans from the previous sample (Sample 2: n = 50; M = 60.06, SD = 4.80), (c) partners of Special Air Services Regiment (SASR) personnel (Sample 3: n = 40, age M = 34.39SD = 7.01), and (d) partners of current serving military (non-SASR) personnel (Sample 4: n = 38, age M = 32.37, SD = 6.20). Respondents completed measures assessing their reported levels of depression, anxiety, and stress. Samples 1 and 2 comprised partners of Australian military veterans who reported significantly greater symptoms of depression, anxiety, and stress than the comparative population norms. The sample of SASR personnel partners (Sample 3) reported significantly lower levels of depression and anxiety, whereas the sample with non-SASR personnel partners (Sample 4) reported a significantly greater stress symptomatology than the comparative norms. Number of deployments was found to be associated with depression, anxiety, and stress in partners of non-SASR veterans (Sample 4). Lessons and protective factors can be learnt from groups within the current military as to what may assist partners and families to maintain a better level of psychosocial health.]]> Wed 11 Apr 2018 13:27:41 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14089 Wed 11 Apr 2018 11:59:36 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11276 Wed 11 Apr 2018 11:31:30 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12338 Wed 11 Apr 2018 10:11:39 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25321 Wed 11 Apr 2018 09:57:51 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27088 Wed 04 Sep 2019 09:39:52 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40274 Thu 07 Jul 2022 12:58:40 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7405 Sat 24 Mar 2018 08:42:43 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12518 Sat 24 Mar 2018 08:16:02 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:5805 Sat 24 Mar 2018 07:44:54 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30855 Sat 24 Mar 2018 07:26:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28189 Sat 24 Mar 2018 07:23:54 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44550 Mon 17 Oct 2022 10:06:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46474 N = 220) with current depressive symptoms and alcohol misuse were recruited from the DAISI project, a randomised controlled trial with four treatment arms. PTSD symptoms were assessed at baseline by the Posttraumatic Stress Diagnostic Scale and again at the 3-month assessment. Results: McNemars t-test assessed for changes in PTSD symptom severity and PTSD symptom clusters at the 3-month assessment. Repeated measures multivariate analysis of variance assessed for changes in PTSD symptoms, by DAISI treatment allocation. At the 3-month assessment, participants with PTSD reported significant reductions in PTSD symptoms (except intrusion) and a lower rate of PTSD, and responded better to integrated depression-alcohol misuse CBT than to the alcohol/depression single-focussed or brief interventions. Conclusion: Integrated depression and alcohol misuse CBT may be effective for PTSD symptoms, but intrusions may need to be addressed specifically.]]> Fri 25 Nov 2022 15:45:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34254 Fri 22 Feb 2019 16:55:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41825 Fri 12 Aug 2022 12:52:18 AEST ]]>